Scientific Category: Thrombosis and Hemostasis Plasminogen is a key pro-inflammatory regulator that accelerates the healing of acute and diabetic wounds Short Title: Plasminogen heals diabetic wounds
نویسندگان
چکیده
*Address for correspondence: Tor Ny, Department of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden; e-mail: [email protected]; Phone: +46 73 620 5065; Fax: +46 90 786 9795 Jinan Li, Department of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden; e-mail: [email protected]. Blood First Edition Paper, prepublished online May 4, 2012; DOI 10.1182/blood-2012-01-407825
منابع مشابه
Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds.
Despite decades of research on wound healing, effective biologic agents for the treatment of chronic wounds, especially diabetic wounds, are still lacking. In the present study, we report that the inert plasma protein plasminogen (plg) acts as a key regulatory molecule that potentiates wound healing in mice. Early in the healing process, plg bound to inflammatory cells is transported to the wou...
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Wound healing and reduction of its recovery time is one of the most important issues in medicine. Wound is defined as disruption of anatomy and function of normal skin. This injury could be the result of physical elements such as surgical incision, hit or pressure cut of the skin and gunshot wound. Chemical or caustic burn is another category of wound causes that can be induced by acid or base...
متن کاملNeuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes.
Dysfunction of macrophages (MΦs) in diabetic wounds impairs the healing. MΦs produce anti-inflammatory and pro-resolving neuroprotectin/protectin D1 (NPD1/PD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid); however, little is known about endogenous NPD1 biosynthesis by MΦs and the actions of NPD1 on diabetic MΦ functions in diabetic wound healing. We used an excisional skin wou...
متن کاملTitle Page Full Title Epigenetic Changes in Bone Marrow Progenitor Cells Influence the Inflammatory Phenotype and Alter Wound Healing in Type 2 Diabetes Short Running Title Epigenetics Impair Diabetic Wound Healing Authors
Classically-activated (M1) macrophages are known to play a role in the development of chronic inflammation associated with impaired wound healing in Type 2 diabetes (T2D); however, the mechanism responsible for the dominant pro-inflammatory (M1) macrophage phenotype in T2D wounds is unknown. Since epigenetic enzymes can direct macrophage phenotypes, we assessed the role of histone methylation i...
متن کاملHealing of excisional wound in Alloxan induced diabetic sheep: A planimetric and histopathologic study
Healing of skin wound is a multi-factorial and complex process. Proper treatment of diabetic wounds is still a major clinical challenge. Although diabetes mellitus can occur in ruminants, healing of wounds in diabetic ruminants has not yet been investigated. The aim of this study was to evaluate healing of ovine excisional diabetic wound model. Eight 4-month-old Iranian Makoui wethers were equa...
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تاریخ انتشار 2012